B-Raf IN 1

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Chemical Structure| 950736-05-7 同义名 : B-RAF Inhibitor 1
CAS号 : 950736-05-7
货号 : A292940
分子式 : C29H24F3N5O
纯度 : 99%+
分子量 : 515.53
MDL号 : MFCD25977055
存储条件：

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 65 mg/mL(126.08 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 B-Raf IN 1 demonstrates potent anti-cancer activity with low micromolar IC50 values against WM 266-4 and HT29 cell lines. This suggests its potential utility in targeting cancers with B-Raf mutations or dependencies[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.94mL

0.39mL

0.19mL

9.70mL

1.94mL

0.97mL

19.40mL

3.88mL

1.94mL
参考文献

[1]Berger DM, et al. Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6519-23.