Human CLEC4C (N-Fc, HEK293)
产品说明书
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同义名 : | 重组人CLEC4C蛋白(N-Fc, HEK293) ;Recombinant Human CLEC4C (N-Fc, HEK293); C-type lectin domain family 4 member C; Blood dendritic cell antigen 2 (BDCA-2); C-type lectin superfamily member 7; Dendritic lectin; CD303; CLEC4C; BDCA2; CLECSF11; CLECSF7; DLEC; HECL |
| CAS号 : | N/A | |
| 货号 : | A2926578 | |
| 分子式 : | - | |
| 纯度 : | 95% determined by reducing SDS-PAGE. | |
| 分子量 : | 45.7 KDa | |
| MDL号 : | - | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -70°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - |
| 生物活性 | |||
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| 描述 | CD303 (BDCA-2) is a type II c-type lectin specifically expressed by human PDC. CD303 has a putative mannose specificity due to an EPN motif in its C-terminal, extracellular domain. CD303 signaling induces tyrosine phosphorylation and Src kinase dependent calcium influx. CD303 is a specific surface marker of human pDCs, centrally involved in antigen presentation and immune tolerance. Monoclonal antibodies directed against CD303 have been studied in preclinical models and have achieved disease control in patients with cutaneous lupus erythematosus. | ||