Human Mucin-1 (1036-1155, C-6His , HEK293)
产品说明书
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同义名 : | 重组人Mucin-1蛋白(1036-1155, C-6His, HEK293) ;Recombinant Human Mucin-1 (1036-1155, C-6His , HEK293); Mucin-1; MUC-1; Breast carcinoma-associated antigen DF3; Cancer antigen 15-3; CA 15-3; Carcinoma-associated mucin; Episialin; H23AG; Krebs von den Lungen-6; KL-6; PEMT; Peanut-reactive urinary mucin; PUM; Polymorphic epithelial mucin; PEM; Tumor-associated epithelial membrane antigen; EMA; Tumor-associated mucin; CD227; MUC1 |
| CAS号 : | N/A | |
| 货号 : | A2926570 | |
| 分子式 : | - | |
| 纯度 : | 95% determined by reducing SDS-PAGE. | |
| 分子量 : | 14.3 KDa | |
| MDL号 : | - | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - |
| 生物活性 | |||
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| 描述 | Mucin 1, known as MUC1 in humans and Muc1 in other mammals, is a multifunctional protein expressed on the apical surface of most epithelial cells. The numerous biological activities attributed to MUC1/Muc1 in promoting cell growth and survival, are sometimes overshadowed by its name and classification as a tethered mucin. The numerous biological activities attributed to MUC1/Muc1 in promoting cell growth and survival, are sometimes overshadowed by its name and classification as a tethered mucin. Muc1 is protective in the kidney in a mouse model of ischemia–reperfusion injury (IRI) by transactivation of the hypoxia-inducible factor 1 (HIF1) and b-catenin protective pathways. MUC1 does have an exceptionally strong glycan-dependent apical targeting signal that can redirect a basolaterally expressed protein to the apical cell surface in polarized epithelia; and the rate of MUC1 recycling from endosome to the cell surface is quite efficient and significantly higher than its rate of endocytosis (four-fold). | ||