Human ROR1 (Ig-like domain, C-6His, HEK293)
产品说明书
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同义名 : | 重组人ROR1蛋白(Ig-like domain, C-6His, HEK293) ;Recombinant Human ROR1 (Ig-like domain, C-6His, HEK293); Inactive tyrosine-protein kinase transmembrane receptor ROR1; Neurotrophic tyrosine kinase, receptor-related 1; ROR1; NTRKR1 |
| CAS号 : | N/A | |
| 货号 : | A2926450 | |
| 分子式 : | - | |
| 纯度 : | 95% determined by reducing SDS-PAGE. | |
| 分子量 : | 13.4 KDa | |
| MDL号 : | - | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - |
| 生物活性 | |||
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| 描述 | Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the ROR receptor family consisting of two closely related type I transmembrane proteins ROR1 and ROR2. Receptor tyrosine kinase like orphan receptor (ROR) family of proteins belongs to the noncanonical wingless-related integration site (Wnt) signaling pathway, closely related to MuSK (muscle-specific kinase) and Trk (tropomyosin) family receptors. The extracellular region (ectodomain) contains an immunoglobulin-like domain (IgG), a cysteine-rich domain (CRD) with sequence and structural similarities to the CRD of Frizzled proteins followed by a Kringle domain. A single transmembrane helix connects the ectodomain to the cytoplasmic region, which contains a tyrosine kinase-like or pseudokinase domain followed by two serine/threonine (Ser/Thr) rich domains flanking a proline (Pro)-rich domain. A combination therapy with ROR1- and BCR-targeted agents for ROR1-positive B-cell malignancies will probably be clinically advantageous. | ||