Human CD20 (C-6His-Flag, HEK293)

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Chemical Structure| N/A 同义名 : 重组人CD20蛋白(C-6His-Flag, HEK293) ;Recombinant Human CD20 (C-6His-Flag, HEK293); B-lymphocyte antigen CD20; B-lymphocyte surface antigen B1; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; Bp35; CD20; MS4A1
CAS号 : N/A
货号 : A2926350
分子式 : -
纯度 : 80% determined by reducing SDS-PAGE.
分子量 : 35.1 kDa
MDL号 : -
存储条件：

Pure form Sealed in dry, store in freezer, under -70°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 CD20 is a 33-37 kDa non-glycosylated protein expressed on the surface of normal and malignant B lymphocytes, and belongs to the MS4A (membrane-spanning 4-domain family A) protein family. CD20 protein consists of four hydrophobic transmembrane domains, one intracellular and two extracellular domains (large and small loops) with both N- and C- termini residing within the cytosol. CD20 is also known to be physically coupled to major histocompatibility complex class II (MHCII), CD40 molecule, BCR, and the C-terminal src kinase-binding protein (CBP) that interacts with Src kinases such as LYN, FYN, and LCK. CD20 deficiency resulted in a reduced number of circulating memory B cells, reduced isotype switching of Ig, and decreased IgG antibody levels. In agreement with this observation, challenging the patient’s primary B cells in vitro using T-dependent and Tindependent antigens led to the normal proliferation and secretion of IgM but reduced production of IgG.