Human CD161 (N-Fc, HEK293)
产品说明书
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同义名 : | 重组人CD161蛋白(N-Fc, HEK293) ;Recombinant Human CD161 (N-Fc, HEK293); Killer cell lectin-like receptor subfamily B member 1; KLRB1; CLEC5B; NKRP1A; CD161; Natural killer cell surface protein P1A; NKR-P1A; HNKR-P1a; C-type lectin domain family 5 member B; KLRB1 |
| CAS号 : | N/A | |
| 货号 : | A2926327 | |
| 分子式 : | - | |
| 纯度 : | 95% determined by reducing SDS-PAGE. | |
| 分子量 : | 45 KDa | |
| MDL号 : | - | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - |
| 生物活性 | |||
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| 描述 | Killer cell lectin-like receptor subfamily B, member 1(KLRB1) is a single-pass type II membrane protein which contains 1 C-type lectin domain. KLRB1 plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. It acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. | ||