2019-nCoV Guanine-N7_meth (N-6His, E.coli)
产品说明书
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同义名 : | 重组2019-nCoV Guanine-N7_meth蛋白(N-6His, E.coli) ;Recombinant 2019-nCoV Guanine-N7_meth (N-6His, E.coli); SARS-CoV 2 nsp14; SARS-CoV 2 ExoN; Guanine-N7 methyltransferase |
| CAS号 : | N/A | |
| 货号 : | A2926244 | |
| 分子式 : | - | |
| 纯度 : | 85% determined by reducing SDS-PAGE. | |
| 分子量 : | 62.9 KDa | |
| MDL号 : | - | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -70°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - |
| 生物活性 | |||
|---|---|---|---|
| 描述 | The nonstructural protein (nsp) 14 of SARS-CoV 2 was identified as a cap (guanine-N7)-methyltransferase (N7-MTase). Nsp14 of coronaviruses two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity. It may be involved in the proof-reading ability during the viral RNA replication and transcription. GTP, dGTP as well as cap analogs GpppG, GpppA and m7GpppG could be methylated by nsp14. | ||