Human CFH (C-6His, HEK293)

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Chemical Structure| N/A 同义名 : 重组人CFH蛋白(C-6His, HEK293) ;Recombinant Human CFH (C-6His, HEK293); Complement factor H; CFH
CAS号 : N/A
货号 : A2926143
分子式 : -
纯度 : 95% determined by reducing SDS-PAGE.
分子量 : 50 KDa
MDL号 : -
存储条件：

Pure form Sealed in dry, store in freezer, under -70°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 Complement Factor H (CFH) is a secreted protein which is a member of the regulators of complement activation family and is a complement control protein. It is expressed by the liver and secreted in plasma. Its principal function is to regulate the Alternative Pathway of the complement system, ensuring that the complement system is directed towards pathogens or other dangerous material and does not damage host tissue. Factor H regulates complement activation on self cells and surfaces by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3-convertase, C3bBb. Factor H exerts its protective action on self cells and self surfaces but not on the surfaces of bacteria or viruses, because it binds to glycosaminoglycans (GAGs) that are generally present on host cells but not, normally, on pathogen surfaces.