Human KRAS (G12V, N-6His, E.coli)
产品说明书
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同义名 : | 重组人KRAS(G12V)蛋白(N-6His, E.coli) ;Recombinant Human KRAS (G12V, N-6His, E.coli); Ki-Ras; c-K-ras; KRAS2; RASK2; CFC2 |
| CAS号 : | N/A | |
| 货号 : | A2925524 | |
| 分子式 : | - | |
| 纯度 : | 95% determined by reducing SDS-PAGE. | |
| 分子量 : | 23.6 KDa | |
| MDL号 : | - | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - |
| 生物活性 | |||
|---|---|---|---|
| 描述 | K-Ras belongs to the small GTPase superfamily, Ras family. As other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes because of the presence of an isoprenyl group on its C-terminus. K-Ras functions as a molecular on/off switch. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner. Besides essential function in normal tissue signaling, the mutation of a K-Ras gene is an essential step in the development of many cancers. Several germline K-Ras mutations have been found to be associated with Noonan syndrome[4] and cardio-facio-cutaneous syndrome. Somatic K-Ras mutations are found at high rates in Leukemias, colon cancer, pancreatic cancer and lung cancer. | ||