Mouse IL-21R (C-6His, HEK293)

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Chemical Structure| N/A 同义名 : 重组小鼠IL-21R蛋白(C-6His, HEK293) ;Recombinant Mouse IL-21R (C-6His, HEK293); Interleukin-21 receptor; IL-21 receptor; IL-21R; Il21r; Nilr
CAS号 : N/A
货号 : A2925277
分子式 : -
纯度 : 95% determined by reducing SDS-PAGE.
分子量 : 25.7 KDa
MDL号 : -
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 Interleukin-21 receptor (IL-21R) is a type I transmembrane glycoprotein within the class I cytokine receptor family, type 4 subfamily. IL-21R is expressed mainly on B cells, NK cells, and activated T cells, but is also found on dendritic cells, alternatively activated macrophages, intestinal lamina propria fibroblasts and epithelial cells, and keratinocytes. Both IL-21 and IL-4 are necessary for efficient B cell IgG1 production and normal germinal center architecture. B cell IL-21 R engagement induces Blimp-1(which mediates plasma cell differentiation), and is important for memory responses. IL-21R engagement on mouse NK cells enhances their cytotoxic activity and IFN-γ production. IL-21R engagement on CD8+ T cells aids control of viral infection and tumor growth; IL-21R is also necessary for sufficient numbers of regulatory T cells to combat chronic inflammation. IL-21R expression is often up-regulated in allergic skin inflammation, systemic lupus erythematosus and diffuse large B cell lymphoma (DLBCL).