Rabbit B7-1 (C-6His, HEK293)

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Chemical Structure| N/A 同义名 : 重组兔B7-1蛋白(C-6His, HEK293) ;Recombinant Rabbit B7-1 (C-6His, HEK293); T-lymphocyte activation antigen CD80; Activation B7-1 antigen; B7; CD80
CAS号 : N/A
货号 : A2925162
分子式 : -
纯度 : 95% determined by reducing SDS-PAGE.
分子量 : 24.5 KDa
MDL号 : -
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response.