Human SIRPA (C-mIgG2aFc, HEK293)

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Chemical Structure| N/A 同义名 : 重组人SIRPA蛋白(C-mIgG2a Fc, HEK293) ;Recombinant Human SIRPA (C-mIgG2aFc, HEK293); Tyrosine-protein phosphatase non-receptor type substrate 1; SHP substrate 1; Signal-regulatory protein alpha-1; p84; CD172a; SIRPA; BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP
CAS号 : N/A
货号 : A2924911
分子式 : -
纯度 : 95% determined by reducing SDS-PAGE.
分子量 : 64.5 KDa
MDL号 : -
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 Signal Regulatory Protein α (SIRPα) is a monomeric approximately 90 kD type I transmembrane glycoprotein. The 504 amino acid human SIRPα contains two Ig-like C1-type domains and one Ig-like V-type domain. SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPα shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRPα engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation.