Rat HER2 (C-6His, E.coli)
产品说明书
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同义名 : | 重组大鼠HER2蛋白(C-6His, E.coli) ;Recombinant Rat HER2 (C-6His, E.coli); Receptor tyrosine-protein kinase erbB-2; Epidermal growth factor receptor-related protein; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; p185erbB2; p185neu; CD340; ERBB2 |
| CAS号 : | N/A | |
| 货号 : | A2924864 | |
| 分子式 : | - | |
| 纯度 : | 95% determined by reducing SDS-PAGE. | |
| 分子量 : | 29.3 KDa | |
| MDL号 : | - | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - |
| 生物活性 | |||
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| 描述 | ERBB2 belongs to the protein kinase superfamily, Tyr protein kinase family and EGF receptor subfamily. It contains a protein kinase domain. ERBB2 is widely expressed in epithelial cells, and amplification and/or overexpression of ErbB2 has been reported associated with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate and ovarian cancers. Rat ERBB2 is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. ErbB2 mediates signalling pathways which involve mitogen-activated protein kinase and phosphatidylinositol-3 kinase, this receptor plays a key role in development, cell proliferation and differentiation. | ||