Mouse CFH (C-6His, HEK293)

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Chemical Structure| N/A 同义名 : 重组小鼠CFH蛋白(C-6His, HEK293) ;Recombinant Mouse CFH (C-6His, HEK293); Complement factor H; Protein beta-1-H; CFH
CAS号 : N/A
货号 : A2924695
分子式 : -
纯度 : 95% determined by reducing SDS-PAGE.
分子量 : 43.4 KDa
MDL号 : -
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 Complement factor H(CFH) is a 155 kDa glycoprotein that functions as a cofactor in the inactivation of C3b by factor I. It also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway. CFH expressed by the liver and secreted in plasma. This recombinant protein corresponds to SCR15-20 which encompass the primary binding sites for heparin and C3b as well as for the peptide hormone adrenomedullin. Within SCR15-20, mouse Factor H shares 60% and 80% amino acid sequence identity with human and rat Factor H, respectively. Dozens of mutations clustered in SCR15-20 are associated with atypical hemolytic uremic syndrome, a disorder characterized by anemia, thrombocytopenia, and renal failure.