Human CDKN1B (N-6His, E.coli)
产品说明书
 |
同义名 : | 重组人CDKN1B蛋白(N-6His, E.coli) ;Recombinant Human CDKN1B (N-6His, E.coli); Cyclin-Dependent Kinase Inhibitor 1B; Cyclin-Dependent Kinase Inhibitor p27; p27Kip1; CDKN1B; KIP1 |
| CAS号 : | N/A | |
| 货号 : | A2924331 | |
| 分子式 : | - | |
| 纯度 : | 95% determined by reducing SDS-PAGE. | |
| 分子量 : | 24.2 KDa | |
| MDL号 : | - | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skeletal muscle. CDKN1B is a potent inhibitor of Cyclin E- and Cyclin A-CDK2 complexes. CDKN1B forms a complex with Cyclin Type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. In addition, CDKN1B acts as an inhibitor or an activator of Cyclin Type D-CDK4 complexes depending on its phosphorylation state and stoichometry. | ||