Human FGFR2IIIb (C-6His)

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Chemical Structure| N/A 同义名 : 重组人FGFR2IIIb蛋白(HEK293, C-6His) ;Recombinant Human FGFR2IIIb (C-6His)
CAS号 : N/A
货号 : A2900910
分子式 : -
纯度 : 95% >=95% as determined by reducing SDS-PAGE.
分子量 : 0
MDL号 : N/A
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 产品名称：Recombinant Human FGFR2 beta IIIb (C-6His)
理论分子量：26.2 KDa
蛋白种属：Human
表达系统：Human Cells
蛋白表达区间：Arg152-Glu378 
标签：C-6His
剂型：干粉
纯度：≥95% as determined by reducing SDS-PAGE.
储存条件：冻干蛋白应储存在≤-20°C，收到后可稳定保存一年。
溶解后的蛋白溶液可以在2-8°C下保存2-7天。如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
产品背景：FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. A frequent splicing event involving FGF R1 and 2 results in receptors containing all three Ig domains, referred to as the alpha isoform, or only IgII and IgIII, referred to as the beta isoform. Only the alpha isoform has been identified for FGF R3 and FGF R4. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.