Human/Mouse/Rat TGF-beta 3
产品说明书
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同义名 : | 重组人/小鼠/大鼠TGFB3蛋白(HEK293, tag free) ;Recombinant Human/Mouse/Rat TGFB3; Transforming growth factor beta-3; TGFB3; TGF-beta-3; Latency-associated peptide; LAP |
| CAS号 : | N/A | |
| 货号 : | A2900893 | |
| 分子式 : | - | |
| 纯度 : | 95% determined by reducing SDS-PAGE. | |
| 分子量 : | 12.7 KDa | |
| MDL号 : | - | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regulate molecules involved in cellularadhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3,mammals develop a deformity known as a cleft palate. | ||