Mouse CREG (C-6His)
产品说明书
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同义名 : | 重组小鼠CREG蛋白(HEK293, C-6His) ;Recombinant Mouse CREG (C-6His) |
| CAS号 : | N/A | |
| 货号 : | A2900839 | |
| 分子式 : | - | |
| 纯度 : | 95% >=95% as determined by reducing SDS-PAGE. | |
| 分子量 : | 0 | |
| MDL号 : | - | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | 产品名称：Recombinant Mouse CREG (C-6His)理论分子量：22.5 KDa蛋白种属：Mouse表达系统：Human Cells蛋白表达区间：Arg32-Gln220标签：C-6His剂型：干粉纯度：≥95% as determined by reducing SDS-PAGE.储存条件：冻干蛋白应储存在≤-20°C，收到后可稳定保存一年。 溶解后的蛋白溶液可以在2-8°C下保存2-7天。如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。 分装后的蛋白在≤-20°C 下可稳定保存 3 个月。产品背景：Cellular repressor of E1A genes (CREG) is an evolutionarily conserved lysosomal protein, and an important new factor in regulating tissue homeostasis that has been shown to antagonize injury of tissues or cells. CREG contains three mannose 6-phosphate (M6P) markers, and depends on interactions with M6P receptors for efficient delivery to lysosomes, which is implicated in the regulation of lysosomal functions. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. CREG plays an important role in the control of cell growth and differentiation. It has been shown that CREG antagonizes transcriptional and cellular transformation by the adenoviral E1A oncoprotein, induces differentiation while attenuating cellular proliferation, regulates the levels of the signaling kinases ERK1/2, and mediates glucocorticoid-induced proliferation of ileal epithelial cells. CREG is widely expressed in adult tissues, such as the brain, heart, lungs, liver, intestines and kidneys in mice, but is not markedly expressed in pluripotent embryonic stem cells. | ||