Carvacrol
产品说明书
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同义名 : | 2-甲基-5-异丙基苯酚 ;Cymophenol; p-Cymen-2-ol; Karvakrol; BRN-1860514; Antioxine; NSC 6188; Isopropyl o-cresol |
| CAS号 : | 499-75-2 | |
| 货号 : | A288147 | |
| 分子式 : | C10H14O | |
| 纯度 : | 98% | |
| 分子量 : | 150.22 | |
| MDL号 : | MFCD00002236 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(698.99 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Carvacrol is the major constituent of essential oils derived from plants. It exhibits antimicrobial, antioxidant, anticancer, anti-inflammatory, and anticholinesterase activity[3]. Carvacrol is a monoterpenoid phenol and majorly present in the essential oils of Lamiaceae family plants. Carvacrol treatment significantly reduced the cell viability of PC-3 cells in a dose- and time-dependent manner. Carvacrol prevented cell cycle in G0/G1 that was associated with decline in expression of cyclin D1 and Cyclin-Dependent Kinase 4 (CDK4) and augmented expression of CDK inhibitor p21[4]. Moreover, carvacrol largely reduced the asymmetrical use of the forelimbs induced by unilateral 6-hydroxy-dopamine. Carvacrol dramatically reduced the loss of tyrosine hydroxylase immunostaining both in the substantia nigra and in the striatum that are typical of the model. Carvacrol promotes a marked neuroprotection in the 6-hydroxy-dopamine model of Parkinson's disease[5]. Carvacrol provides protection for hippocampal neurons against I/R in gerbils by inhibiting ferroptosis through increasing the expression of GPx4[6]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
6.66mL 1.33mL 0.67mL |
33.28mL 6.66mL 3.33mL |
66.57mL 13.31mL 6.66mL |
| 参考文献 |
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