MALT1 inhibitor MI-2

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Chemical Structure| 1047953-91-2 同义名 : -
CAS号 : 1047953-91-2
货号 : A286737
分子式 : C19H17Cl3N4O3
纯度 : 99% (HPLC)
分子量 : 455.72
MDL号 : MFCD19754074
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 45 mg/mL(98.74 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 MI-2, a MALT1 inhibitor (IC50=5.84 μM), directly targets MALT1, irreversibly inhibiting its protease activity. This inhibition is associated with decreased NF-κB reporter activity, blocked c-REL nuclear translocation, and reduced expression of NF-κB-dependent genes. MI-2 is non-toxic to animals[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.19mL

0.44mL

0.22mL

10.97mL

2.19mL

1.10mL

21.94mL

4.39mL

2.19mL
参考文献

[1]Fontan L, et al. MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell. 2012 Dec 11;22(6):812-24.