Lisinopril
产品说明书
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同义名 : | MK-521; MK-522 |
| CAS号 : | 76547-98-3 | |
| 货号 : | A285815 | |
| 分子式 : | C21H31N3O5 | |
| 纯度 : | 98% | |
| 分子量 : | 405.49 | |
| MDL号 : | MFCD00214086 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Angiotensin-converting enzyme (ACE) is responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII), which regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS) [3]. Lisinopril (MK-521) is angiotensin-converting enzyme inhibitor with inhibition constant (Ki) value of 0.39 mM, used in treatment of hypertension, congestive heart failure, and heart attacks[4]. Although lisinopril significantly reduced preload, its effect on left ventricular (LV) contractility was insignificant in experimental mitral regurgitation (MR). Conversely, atenolol, when added to lisinopril, achieved maximum hemodynamic benefit and also restored LV contractility [5]. In spontaneously hypertensive rats (SHR) rats, levels of α-tocopherol were substantially reduced in both plasma and cardiac tissue. Treatment with lisinopril ameliorated reduced levels of plasma α-tocopherol in SHR rats [6]. Paraquat caused a significant increase in hydroxyproline content and lisinopril significantly decreased the amount hydroxyproline (p<0.001) in the lung tissue of the rats. The histological examination also indicated that lisinopril can effectively protect the paraquat-induced lung fibrosis [7]. In isolated guinea pig hearts, lisinopril protects the cell membrane integrity and lessens free radical-induced oxidant stress [8]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00567307 | Cardiovascular Disease | Phase 2 | Completed | - | Sri Lanka ... 展开 >> The National Hospital of Sri Lanka Colombo, Sri Lanka, Colombo10 Teaching (General) Hospital Kandy Kandy, Sri Lanka Teaching (General) Hospital Kegalle Kegalle, Sri Lanka 收起 << |
| NCT00292162 | Chronic Heart Failure ... 展开 >> Atrial Fibrillation 收起 << | Not Applicable | Completed | - | United Kingdom ... 展开 >> Glasgow Royal Infirmary Glasgow, Scotland, United Kingdom, G31 2ER 收起 << |
| NCT03461003 | Pediatric Hypertension | Phase 4 | Recruiting | January 2020 | United States, Texas ... 展开 >> The University of Texas Health Science Center at Houston Recruiting Houston, Texas, United States, 77030 Contact: Joyce P Samuel, MD, MS 713-500-5670 joyce.p.samuel@uth.tmc.edu 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.47mL 0.49mL 0.25mL |
12.33mL 2.47mL 1.23mL |
24.66mL 4.93mL 2.47mL |
| 参考文献 |
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