Alpinetin

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Chemical Structure| 36052-37-6 同义名 : -
CAS号 : 36052-37-6
货号 : A265742
分子式 : C16H14O4
纯度 : 99%+
分子量 : 270.28
MDL号 : MFCD00238532
存储条件：

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(184.99 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Alpinetin, a flavonoid compound extracted from the seeds of Alpinia katsumadai Hayata, acted as a potential AhR activator. in vivo, alpinetin (7.5, 15, 30 mg/kg) dose-dependently reduced the myeloperoxidase (MPO) activity. Moreover, alpinetin (15, 30 mg/kg) significantly up-regulated levels of IL-10 and Foxp3 in colons of colitis mice. in vitro, alpinetin (30 μM) could activate AhR in EL-4 cells[3]. The proliferation of A549, SK-MES-1, and NCI-H292 cells was inhibited in a dose- and time-dependent manner by alpinetin treatment[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.70mL

0.74mL

0.37mL

18.50mL

3.70mL

1.85mL

37.00mL

7.40mL

3.70mL
参考文献

[1]Jiang Z, Sang H, et al. Alpinetin enhances cholesterol efflux and inhibits lipid accumulation in oxidized low-density lipoprotein-loaded human macrophages. Biotechnol Appl Biochem. 2015 Nov-Dec;62(6):840-7.

[2]Guan S, Fang B, et al. Immunosuppressive activity of alpinetin on activation and cytokines secretion of murine T lymphocytes. Immunopharmacol Immunotoxicol. 2014 Aug;36(4):290-6.

[3]Lv Q, Shi C, Qiao S, et al. Alpinetin exerts anti-colitis efficacy by activating AhR, regulating miR-302/DNMT-1/CREB signals, and therefore promoting Treg differentiation. Cell Death Dis. 2018;9(9):890. Published 2018 Aug 30.

[4]Wu L, Yang W, Zhang SN, Lu JB. Alpinetin inhibits lung cancer progression and elevates sensitization drug-resistant lung cancer cells to cis-diammined dichloridoplatium. Drug Des Devel Ther. 2015;9:6119-6127. Published 2015 Nov 16.