Amiloride HCl

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Chemical Structure| 2016-88-8 同义名 : MK-870 hydrochloride; Amiloride (hydrochloride); Amiloride HCl anhydrous; MK-870; MK-870 HCl; Amiloride hydrochloride
CAS号 : 2016-88-8
货号 : A262614
分子式 : C6H9Cl2N7O
纯度 : 98%
分子量 : 266.09
MDL号 : MFCD00058197
存储条件：

Pure form

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(394.61 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 7 mg/mL(26.31 mM)，配合低频超声助溶
动物实验配方：
生物活性
靶点

  • Calcium Channel

  • Sodium Channel
描述 Amiloride hydrochloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.76mL

0.75mL

0.38mL

18.79mL

3.76mL

1.88mL

37.58mL

7.52mL

3.76mL
参考文献

[1]Teiwes J, Toto RD. Epithelial sodium channel inhibition in cardiovascular disease. A potential role for amiloride. Am J Hypertens. 2007 Jan;20(1):109-17.

[2]Tang CM, Presser F, et al. Amiloride selectively blocks the low threshold (T) calcium channel. Science. 1988 Apr 8;240(4849):213-5.