SC-79

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Chemical Structure| 305834-79-1 同义名 : -
CAS号 : 305834-79-1
货号 : A261312
分子式 : C17H17ClN2O5
纯度 : 98%
分子量 : 364.78
MDL号 : -
存储条件：

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(287.84 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 50 mg/mL(137.07 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方：

2% DMSO+corn oil 5 mg/mL

生物活性
描述 Akt/PKB is the major molecular in the PI3K pathway. It contains a PH domain that specifically binds PtdIns(3,4,5)P3 on the plasma membrane, which guides AKT to the cell membrane in a process mediated by interaction with the phospholipids then switches AKT to an active form. Elevation of Akt activation is an obvious clinical strategy to prevent progressive neuronal death in neurological diseases. SC79 is a pan-Akt activator, though it suppresses AKT PH-domain plasma membrane translocation. In multiple cell lines, treatment with 1-4ug/ml SC79 can dramatically increase p-AKT. SC79 treatment (4μg/ml) can reduce the hippocampal neuron death induced by glutamate. Intraperitoneal injection of 40mg/kg SC79 can prevent stroke induced Akt deactivation and neuronal death in brain of mouse ischemia model. This also hinted that SC79 was brain-penetrable[1].
作用机制 SC79 can directly bind to AKT and convert AKT to an active conformation, which is more suitable to be phosphorylated by upstream kinases.[1]
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.74mL

0.55mL

0.27mL

13.71mL

2.74mL

1.37mL

27.41mL

5.48mL

2.74mL
参考文献

[1]Jo H, Mondal S, et al. Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10581-6.