SF1670

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Chemical Structure| 345630-40-2 同义名 : -
CAS号 : 345630-40-2
货号 : A260724
分子式 : C19H17NO3
纯度 : 99%+
分子量 : 307.34
MDL号 : MFCD06411448
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(162.68 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • PTEN

    PTEN, IC50:2 μM
描述 SF1670 is a potent and specific phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor[1].
细胞研究
细胞系 浓度 检测类型 检测时间 活性说明 数据源
human T-cell Proliferation assay In vitro inhibition of human T-cell proliferation, IC50=0.1 μM 11356112
human T-cells Cytotoxicity assay Cytotoxicity measured against human T-cells, CC50=3.5 μM 11356112
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.25mL

0.65mL

0.33mL

16.27mL

3.25mL

1.63mL

32.54mL

6.51mL

3.25mL
参考文献

[1]Li Y, et al. Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood. 2011 Jun 16;117(24):6702-13.

[2]Montales MT, et al. Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells. Genes Nutr. 2015 Nov;10(6):49.