Calicheamicin

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Chemical Structure| 108212-75-5 同义名 : Calicheamicin γ1
CAS号 : 108212-75-5
货号 : A255378
分子式 : C55H74IN3O21S4
纯度 : 99%+
分子量 : 1368.35
MDL号 : MFCD30478834
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(18.27 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Calicheamicin is a potent DNA crosslinker cytotoxic antibiotic.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.73mL

0.15mL

0.07mL

3.65mL

0.73mL

0.37mL

7.31mL

1.46mL

0.73mL
参考文献

[1]Chang A, Singh S, et al. Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity. Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17649-54.

[2]Ricart AD. Antibody-drug conjugates of calicheamicin derivative: gemtuzumab ozogamicin and inotuzumab ozogamicin. Clin Cancer Res. 2011 Oct 15;17(20):6417-6427.