Daminozide
产品说明书
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同义名 : | 丁酰肼(B9) ;Alar; Succinic Acid; Kylar SADH; SADH; Kylar; DMASA; DIMG; B 995; Aminozide |
| CAS号 : | 1596-84-5 | |
| 货号 : | A252184 | |
| 分子式 : | C6H12N2O3 | |
| 纯度 : | 98% | |
| 分子量 : | 160.17 | |
| MDL号 : | MFCD00002787 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 100 mg/mL(624.33 mM)，配合水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 100 mg/mL(624.33 mM)，配合低频超声助溶 |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Daminozide, a plant growth regulator, selectively inhibits human KDM2/7 histone demethylases, with IC50 values of 0.55 μM for PHF8, 1.5 μM for KDM2A, and 2.1 μM for KIAA1718. It exhibits over 100-fold selectivity for the KDM2/7 subfamily compared to other demethylase subfamily members tested [1][2]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT03172715 | Tibial Fractures | Not Applicable | Recruiting | June 2029 | Finland ... 展开 >> Central Finland Hospital Recruiting Jyväskylä, Finland, 40620 Contact: Juha Paloneva, MD, PhD +358 14 2693119 Contact: Valtteri Tapper, MD Sub-Investigator: Alar Toom, MD, PhD Sub-Investigator: Valtteri Tapper, MD, PhD Principal Investigator: Juha Paloneva, MD, PhD Sub-Investigator: Heikki Nurmi, MD, PhD Sub-Investigator: Maija Pesola, MD, PhD Sub-Investigator: Konsta Pamilo, MD, PhD Kuopio University Hospital Not yet recruiting Kuopio, Finland Contact: Jussi Jalkanen, MD Principal Investigator: Jussi Jalkanen, MD, PhD Sub-Investigator: Tommi Kääriäinen, MD, PhD Päijät-Häme Central Hospital Not yet recruiting Lahti, Finland Contact: Jussi Haapala, MD, PhD Principal Investigator: Jussi Haapala, MD, PhD Sub-Investigator: Sami Nurmi, MD Oulu University Hospital Not yet recruiting Oulu, Finland Contact: Tuukka Niinimäki, MD, PhD Principal Investigator: Tuukka Niinimäki, MD, PhD Sub-Investigator: Tero Kortekangas, MD, PhD Seinäjoki Central Hospital Not yet recruiting Seinäjoki, Finland Contact: Janne Jousmäki, MD, PhD Principal Investigator: Janne Jousmäki, MD, PhD Sub-Investigator: Ville Sumuvuori, MD, PhD Coxa Joint Replacement Hospital Not yet recruiting Tampere, Finland Contact: Jyrki Nieminen, MD Principal Investigator: Jyrki Nieminen, MD, PhD Tampere University Hospital Not yet recruiting Tampere, Finland Contact: Minna Laitinen, MD, PhD Principal Investigator: Ilari Pajamäki, MD Turku University Hospital Not yet recruiting Turku, Finland Contact: Niko Strandberg, MD, PhD Principal Investigator: Niko Strandberg, MD, PhD Sub-Investigator: Mika Junnila, MD, PhD 收起 << |
| NCT02188355 | - | Recruiting | September 2019 | - | |
| NCT02336243 | Premature Birth ... 展开 >> Preeclampsia Fetal Growth Retardation Stillbirth 收起 << | Phase 3 | Unknown | April 2018 | Chile ... 展开 >> Centro de Salud Familiar ANCORA Juan Pablo II Recruiting Santiago, Chile Contact: Francisco Arancibia, Matron Contact +56 2 2482 2400 Centro de Salud Familiar ANCORA Madre Teresa de Calcuta Recruiting Santiago, Chile Contact: Patricia Alar, Enf Matrona Contact +56 2 2851 5211 Centro de Salud Familiar ANCORA San Alberto Hurtado Recruiting Santiago, Chile Contact: Ghislaine Bustamante, Matrona Contact +56 2 2587 9300 Centro Medico Lira 85 Recruiting Santiago, Chile Contact: Cecilia Berrios, Enf Matrona Contact +56 2 2354 8077 Centro Medico San Joaquin Recruiting Santiago, Chile Contact: Veronica Nuñez, Enf Matrona Contact +56 2 2354 8540 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
6.24mL 1.25mL 0.62mL |
31.22mL 6.24mL 3.12mL |
62.43mL 12.49mL 6.24mL |
| 参考文献 |
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