WYE-687

产品说明书

Print
Chemical Structure| 1062161-90-3 同义名 : WAY-687
CAS号 : 1062161-90-3
货号 : A251595
分子式 : C28H32N8O3
纯度 : 98%
分子量 : 528.61
MDL号 : MFCD22417086
存储条件：

Pure form

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(47.29 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • mTOR

    mTOR, IC50:7 nM
描述 WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM showing > 100 fold selectivity for mTOR than PI3Kα/γ.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.89mL

0.38mL

0.19mL

9.46mL

1.89mL

0.95mL

18.92mL

3.78mL

1.89mL
参考文献

[1]Pan XD, Gu DH, et al. Concurrent inhibition of mTORC1 and mTORC2 by WYE-687 inhibits renal cell carcinoma cell growth in vitro and in vivo. PLoS One. 2017 Mar 3;12(3):e0172555.

[2]Cheng F, Wang L, et al. Preclinical evaluation of WYE-687, a mTOR kinase inhibitor, as a potential anti-acute myeloid leukemia agent. Biochem Biophys Res Commun. 2016 Feb 5;470(2):324-330.