Dexamethasone phosphate disodium

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Chemical Structure| 2392-39-4 同义名 : 地塞米松磷酸二钠 ;Dexamethasone 21-phosphate disodium; Dexamethasone Phosphate (sodium salt); Dexamethasone 21-phosphate disodium salt; Maxidex; Hexadrol; Dexair; Decadron; Dexacort; DEX
CAS号 : 2392-39-4
货号 : A249567
分子式 : C22H28FNa2O8P
纯度 : 99%
分子量 : 516.4
MDL号 : MFCD00079105
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 1 mg/mL(1.94 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(193.65 mM)
动物实验配方：

PO 0.5% CMC-Na 40 mg/mL clear

生物活性
描述 Dexamethasone phosphate disodium, a glucocorticoid receptor agonist, is recognized for its oral activity and potent anti-inflammatory effects[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.94mL

0.39mL

0.19mL

9.68mL

1.94mL

0.97mL

19.36mL

3.87mL

1.94mL
参考文献

[1]LaLone CA, et al. Effects of a glucocorticoid receptor agonist, Dexamethasone, on fathead minnow reproduction, growth, and development. Environ Toxicol Chem. 2012 Mar;31(3):611-22.

[2]Adcock IM, et al. Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement. Br J Pharmacol. 1999 Jun;127(4):1003-11.

[3]Rocksén D, et al. Differential anti-inflammatory and anti-oxidative effects of Dexamethasone and N-acetylcysteine in endotoxin-induced lung inflammation. Clin Exp Immunol. 2000 Nov;122(2):249-56.

[4]Roussel D, et al. Dexamethasone treatment specifically increases the basal proton conductance of rat liver mitochondria. FEBS Lett. 2003 Apr 24;541(1-3):75-9.