Panobinostat lactate

产品说明书

Print
Chemical Structure| 960055-56-5 同义名 : LBH589 lactate; NVP-LBH589 lactate
CAS号 : 960055-56-5
货号 : A244814
分子式 : C24H29N3O5
纯度 : 97%
分子量 : 439.5
MDL号 : N/A
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Panobinostat lactate is a potent, orally active, non-selective HDAC inhibitor.Panobinostat lactate has antitumour activity. It is also effective in disrupting HIV latency.Panobinostat lactate induces apoptosis and autophagy and may be used in the study of refractory or recurrent multiple myeloma[1][2][3][4][5].Panobinostat lactate induces apoptosis in MOLT-4 and Reh cells in a time- and dose-dependent manner, leading to hyperacetylation of histones (H3K9 and H4K8) and regulation of cell cycle control genes in Reh cells [1].Panobinostat lactate showed potent antiproliferative activity in human NSCLC cell lines with IC50 values ranging from 5 to 100 nM [2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.28mL

0.46mL

0.23mL

11.38mL

2.28mL

1.14mL

22.75mL

4.55mL

2.28mL
参考文献

[1]Scuto A, et al. The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells. Blood. 2008 May 15;111(10):5093-100.

[2]Crisanti MC, et al. The HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and lung cancer cells in vitro and in vivo with particular efficacy for small cell lung cancer. Mol Cancer Ther. 2009 Aug;8(8):2221-31.

[3]Ocio EM, et al. In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma. Haematologica. 2010 May;95(5):794-803.

[4]Banerjee NS, et al. Vorinostat, a pan-HDAC inhibitor, abrogates productive HPV-18 DNA amplification. Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):E11138-E11147.

[5]Barton K, et al. Broad activation of latent HIV-1 in vivo. Nat Commun. 2016;7:12731. Published 2016 Sep 8.