MK-0608

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Chemical Structure| 443642-29-3 同义名 : -
CAS号 : 443642-29-3
货号 : A244674
分子式 : C12H16N4O4
纯度 : 95%
分子量 : 280.28
MDL号 : MFCD14584964
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(891.97 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 MK-0608 is a potent oral inhibitor of HCV replication in vitro with an EC50 of 0.3 μM in a subgenomic replicon assay [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.57mL

0.71mL

0.36mL

17.84mL

3.57mL

1.78mL

35.68mL

7.14mL

3.57mL
参考文献

[1]Carroll SS, et al. Robust antiviral efficacy upon administration of a nucleoside analog to hepatitis C virus-infected chimpanzees. Antimicrob Agents Chemother. 2009 Mar;53(3):926-34.