Atglistatin

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Chemical Structure| 1469924-27-3 同义名 : -
CAS号 : 1469924-27-3
货号 : A241114
分子式 : C17H21N3O
纯度 : 99%+
分子量 : 283.37
MDL号 : MFCD28009494
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(370.54 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • Lipase

    ATGL, IC50:0.7 μM
描述 Atglistatin targets the triacylglycerol (TG) hydrolase activity of adipose triglyceride lipase (ATGL) in white adipose tissue (WAT), inhibiting it in a dose-dependent manner and achieving up to a 78% reduction at the highest tested concentration. In WAT lysates from ATGL knockout (ko) animals, where TG hydrolase activity is already diminished by about 70%, Atglistatin exerts a moderate effect on the remaining activity. This suggests that the majority of the non-ATGL related TG hydrolase activity can be attributed to hormone-sensitive lipase (HSL), especially since the combined inhibition with Atglistatin and an HSL inhibitor nearly abolishes TG hydrolase activity in WAT (-95%)[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.53mL

0.71mL

0.35mL

17.64mL

3.53mL

1.76mL

35.29mL

7.06mL

3.53mL
参考文献

[1]Mayer N, et al. Development of small-molecule inhibitors targeting adipose triglyceride lipase. (2013) Nat Chem Biol. 9(12):785-7.