UNC926

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Chemical Structure| 1184136-10-4 同义名 : -
CAS号 : 1184136-10-4
货号 : A233602
分子式 : C16H21BrN2O
纯度 : 99%
分子量 : 337.25
MDL号 : MFCD23098916
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 40 mg/mL(118.6 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • bromodomain

    L3MBTL1, Kd:3.9 μM
描述 UNC926 is an improved L3MBTL inhibitor with IC50 values of 3.9μM, 3.2μM and 15.6μM for L3MBTL1, L3MBTL3 and L3MBTL4, respectively. UNC926 selectively interfered with the binding of L3MBTL13xMBT to H4K20me1[2].
作用机制 UNC926 is a small molecule ligand for a methyl-lysine binding domain.[2]
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.97mL

0.59mL

0.30mL

14.83mL

2.97mL

1.48mL

29.65mL

5.93mL

2.97mL
参考文献

[1]James LI, Korboukh VK, et al. Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3. J Med Chem. 2013 Sep 26;56(18):7358-71.

[2]James LI, Korboukh VK, Krichevsky L, Baughman BM, Herold JM, Norris JL, Jin J, Kireev DB, Janzen WP, Arrowsmith CH, Frye SV. Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3. J Med Chem. 2013 Sep 26;56(18):7358-71. doi: 10.1021/jm400919p. Epub 2013 Sep 16. PMID: 24040942; PMCID: PMC3846386.