Ambroxol

产品说明书

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Chemical Structure| 18683-91-5 同义名 : 氨溴索碱 ;NA-872
CAS号 : 18683-91-5
货号 : A233160
分子式 : C13H18Br2N2O
纯度 : 98+%
分子量 : 378.1
MDL号 : MFCD00242702
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 190 mg/mL(502.51 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • Sodium Channel

    Sodium channel, IC50:35.2 μM-22.5 μM
描述 Ambroxol is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02373891 Healthy Volunteers Phase 1 Completed - -
NCT03177889 Bronchiectasis Adult ... 展开 >> Traditional Chinese Medicine Quality of Life Exacerbation 收起 << Not Applicable Not yet recruiting December 31, 2019 -
NCT02395913 Healthy Male Phase 1 Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.64mL

0.53mL

0.26mL

13.22mL

2.64mL

1.32mL

26.45mL

5.29mL

2.64mL
参考文献

[1]Mao Z, Wang X, et al. Quantitative Detection of Ambroxol in Human Plasma Using HPLC-APCI-MS/MS: Application to a Pharmacokinetic Study. Anal Sci. 2017;33(10):1099-1103.

[2]Migdalska-Richards A, Ko WKD, et al. Oral ambroxol increases brain glucocerebrosidase activity in a nonhuman primate. Synapse. 2017 Jul;71(7).