STM3006

产品说明书

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Chemical Structure| 2499664-52-5 同义名 : -
CAS号 : 2499664-52-5
货号 : A2289160
分子式 : C25H27BrN8
纯度 : 98%
分子量 : 519.44
MDL号 : N/A
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(231.02 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 STM3006 is a highly potent, selective, and orally active METTL3 inhibitor, with potential in the research of acute myeloid leukaemia (AML)[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.93mL

0.39mL

0.19mL

9.63mL

1.93mL

0.96mL

19.25mL

3.85mL

1.93mL
参考文献

[1]Andrew A Guirguis, et al. Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity.Cancer Discov. 2023 Oct 5;13(10):2228-2247.