GSK-5498A

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Chemical Structure| 1253186-49-0 同义名 : -
CAS号 : 1253186-49-0
货号 : A228881
分子式 : C18H11F6N3O
纯度 : 98+%
分子量 : 399.29
MDL号 : -
存储条件：

Pure form

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(262.97 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 GSK5498A is a selective small molecule blocker of CRAC channel(IC50=1 uM) and inhibit mediator release from mast cells, and pro-inflammatory cytokine release from T-cells in a variety of species.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.50mL

0.50mL

0.25mL

12.52mL

2.50mL

1.25mL

25.04mL

5.01mL

2.50mL
参考文献

[1]Chen J, Sanderson MJ. Store-operated calcium entry is required for sustained contraction and Ca(2+) oscillations of airway smooth muscle. J Physiol. 2017 May 15;595(10):3203-3218.

[2]Rice LV, Bax HJ, et al. Characterization of selective Calcium-Release Activated Calcium channel blockers in mast cells and T-cells from human, rat, mouse and guinea-pig preparations. Eur J Pharmacol. 2013 Mar 15;704(1-3):49-57.