RHPS4

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Chemical Structure| 390362-78-4 同义名 : RHPS 4 methosulfate; NSC714187; RHPS4 (methyl sulfate)
CAS号 : 390362-78-4
货号 : A228165
分子式 : C23H20F2N2O4S
纯度 : 98%
分子量 : 458.48
MDL号 : MFCD30182275
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 1 mg/mL(2.18 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 RHPS4 is a potent inhibitor of Telomerase at submicromolar.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.18mL

0.44mL

0.22mL

10.91mL

2.18mL

1.09mL

21.81mL

4.36mL

2.18mL
参考文献

[1]Phatak P, Cookson JC, et al. Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism. Br J Cancer. 2007 Apr 23;96(8):1223-33.

[2]Salvati E, Leonetti C, et al. Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect. J Clin Invest. 2007 Nov;117(11):3236-47.