UNC 669

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Chemical Structure| 1314241-44-5 同义名 : -
CAS号 : 1314241-44-5
货号 : A223382
分子式 : C15H20BrN3O
纯度 : 99%
分子量 : 338.24
MDL号 : MFCD26936345
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(147.82 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • bromodomain

    L3MBTL3, IC50:35 μM

    L3MBTL4, IC50:6 μM
描述 UNC669 is a selective MBT antagonist with IC50 values of 6μM, 35μM and 69μM for L3MBTL1, 3 and 4, respectively[3]. It inhibits L3MBTL1-methylated histone protein-protein interaction[2].
作用机制 UNC669 is a small molecule ligand for a methyl-lysine binding domain.[2]
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.96mL

0.59mL

0.30mL

14.78mL

2.96mL

1.48mL

29.56mL

5.91mL

2.96mL
参考文献

[1]Herold JM, Wigle TJ, et al. Small-molecule ligands of methyl-lysine binding proteins. J Med Chem. 2011 Apr 14;54(7):2504-11.

[2]Structure–activity relationships of methyl-lysine reader antagonists

[3]Herold JM, Wigle TJ, Norris JL, Lam R, Korboukh VK, Gao C, Ingerman LA, Kireev DB, Senisterra G, Vedadi M, Tripathy A, Brown PJ, Arrowsmith CH, Jin J, Janzen WP, Frye SV. Small-molecule ligands of methyl-lysine binding proteins. J Med Chem. 2011 Apr 14;54(7):2504-11. doi: 10.1021/jm200045v. Epub 2011 Mar 18. PMID: 21417280; PMCID: PMC3109722.