Tyrphostin A9

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Chemical Structure| 10537-47-0 同义名 : Tyrphostin 9; Malonoben; Tyrphostin AG-17; NSC 242557; GCP 5126; AG-17; RG-50872; SF 6847
CAS号 : 10537-47-0
货号 : A219213
分子式 : C18H22N2O
纯度 : 98%
分子量 : 282.38
MDL号 : MFCD00209853
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(177.07 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • EGFR/ErbB1

    EGFR, IC50:460 μM

  • PDGFR

    PDGFR, IC50:0.5 μM
描述 Tyrphostin 9 is firstly designed as an EGFR inhibitor with IC50 of 460 μM, but is also found to be more potent to PDGFR with IC50 of 0.5 μM
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.54mL

0.71mL

0.35mL

17.71mL

3.54mL

1.77mL

35.41mL

7.08mL

3.54mL
参考文献

[1]Yura Y, Kusaka J, et al. Inhibitory effect of tyrphostin on the replication of herpes simplex virus type 1. Arch Virol. 1995;140(7):1181-94.

[2]Gazit A, Yaish P, et al. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem. 1989 Oct;32(10):2344-52.