AICAR phosphate

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Chemical Structure| 681006-28-0 同义名 : Acadesine phosphate; AICA Riboside phosphate
CAS号 : 681006-28-0
货号 : A218352
分子式 : C9H17N4O9P
纯度 : 98+%
分子量 : 356.23
MDL号 : MFCD28167728
存储条件：

Pure form

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 100 mg/mL(280.72 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 AICAR phosphate, is an AMP-activated protein kinase activator, which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.81mL

0.56mL

0.28mL

14.04mL

2.81mL

1.40mL

28.07mL

5.61mL

2.81mL
参考文献

[1]Drake JC, Alway SE, et al. AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1546-54.

[2]Nakamaru K, Matsumoto K, et al. AICAR, an activator of AMP-activated protein kinase, down-regulates the insulin receptor expression in HepG2 cells. Biochem Biophys Res Commun. 2005 Mar 11;328(2):449-54.