Kushenol A

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Chemical Structure| 99217-63-7 同义名 : Leachianone E
CAS号 : 99217-63-7
货号 : A217533
分子式 : C25H28O5
纯度 : 99%
分子量 : 408.49
MDL号 : MFCD21333212
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(257.05 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Kushenol A, a kind of Adenosine 3', 5'-cyclic monophosphate(cAMP)phosphodiesterase inhibitiors isolated and purified from the roots of Sophora flavescens Ait., exhibits inhibitory activity against sodium-dependent glucose cotransporter 2(SGLT2 and shows selective alpha-glucosidase inhibitory activity.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.45mL

0.49mL

0.24mL

12.24mL

2.45mL

1.22mL

24.48mL

4.90mL

2.45mL
参考文献

[1]Kim JH, Ryu YB, et al. Glycosidase inhibitory flavonoids from Sophora flavescens. Biol Pharm Bull. 2006 Feb;29(2):302-5.

[2]Ohmoto T, Aikawa R, et al. Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase by components of Sophora flavescens Aiton. Chem Pharm Bull (Tokyo). 1986 May;34(5):2094-9.