Corynoxine

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Chemical Structure| 6877-32-3 同义名 : 柯诺辛碱
CAS号 : 6877-32-3
货号 : A217354
分子式 : C22H28N2O4
纯度 : 98+%
分子量 : 384.47
MDL号 : N/A
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(273.1 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Corynoxine is an enantiomer of Corynoxine B and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.60mL

0.52mL

0.26mL

13.00mL

2.60mL

1.30mL

26.01mL

5.20mL

2.60mL
参考文献

[1]Chen LL, Song JX, et al. Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathway. J Neuroimmune Pharmacol. 2014 Jun;9(3):380-7.

[2]Sakakibara I, Terabayashi S, et al. Effect on locomotion of indole alkaloids from the hooks of uncaria plants. Phytomedicine. 1999 Jul;6(3):163-8.