Homovanillic acid
产品说明书
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同义名 : | Vanilacetic acid; HVA; Homovanillic acid, HVA, NSC 16682, Vanilacetic Acid; NSC 16682; Vanillacetic acid |
| CAS号 : | 306-08-1 | |
| 货号 : | A215667 | |
| 分子式 : | C9H10O4 | |
| 纯度 : | 95% | |
| 分子量 : | 182.17 | |
| MDL号 : | MFCD00004350 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(576.37 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 8 mg/mL(43.91 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Homovanillic Acid (HVA) is a metabolite of dopamine, reflecting central dopamine metabolism, primarily situated in the striatum[3]. Moreover, reduced CSF (cerebrospinal fluid) HVA in LBD (Lewy body disorder) is supported by the finding that HVA is also reduced in the brains and CSF of PD (Parkinson disease) patients[4].The metoclopramide induced increase of striatal HVA content was dose-dependent[5]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00106353 | Adenocarcinoma ... 展开 >> Neoplasms 收起 << | Phase 1 Phase 2 | Completed | - | - |
| NCT03180762 | Healthy | Phase 1 | Terminated(Trial stopped A SAE... 展开 >> has occured. As a measure of precaution, the trial has been stopped.) 收起 << | - | Belgium ... 展开 >> Clinical Pharmacology Unit Merksem, Belgium, 2170 收起 << |
| NCT00659984 | Neuroblastoma | Phase 2 | Completed | - | United States, California ... 展开 >> Childrens Hospital Los Angeles Los Angeles, California, United States, 90027-0700 Lucile Packard Children's Hospital at Stanford University Medical Center Palo Alto, California, United States, 94304 UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, California, United States, 94115 United States, Illinois University of Chicago Comer Children's Hospital Chicago, Illinois, United States, 60637 United States, Michigan C.S. Mott Children's Hospital at University of Michigan Medical Center Ann Arbor, Michigan, United States, 48109-0286 United States, Ohio Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229-3039 United States, Pennsylvania Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104-4318 United States, Texas Texas Children's Hospital Houston, Texas, United States, 77030 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
5.49mL 1.10mL 0.55mL |
27.45mL 5.49mL 2.74mL |
54.89mL 10.98mL 5.49mL |
| 参考文献 |
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