Ulixertinib HCl
产品说明书
 |
同义名 : | - |
| CAS号 : | 1956366-10-1 | |
| 货号 : | A214234 | |
| 分子式 : | C21H23Cl3N4O2 | |
| 纯度 : | 98% | |
| 分子量 : | 469.79 | |
| MDL号 : | MFCD22543853 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 105 mg/mL(223.5 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Ulixertinib hydrochloride (BVD-523 hydrochloride) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC50 of <0.3 nM against ERK2. Ulixertinib hydrochloride is effective in inhibiting phosphorylated ERK2 (pERK) and the downstream kinase RSK (pRSK) in A375 melanoma cells[1].[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.13mL 0.43mL 0.21mL |
10.64mL 2.13mL 1.06mL |
21.29mL 4.26mL 2.13mL |
| 参考文献 |
|---|