ACY-738

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Chemical Structure| 1375465-91-0 同义名 : -
CAS号 : 1375465-91-0
货号 : A213388
分子式 : C14H14N4O2
纯度 : 99%+
分子量 : 270.29
MDL号 : MFCD28347706
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(110.99 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • HDAC6

    HDAC6, IC50:1.7 nM
描述 ACY-738 at a concentration of 2.5 μM increases the acetylation of α-tubulin at lysine 40 in RN46A-B14 cells[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.70mL

0.74mL

0.37mL

18.50mL

3.70mL

1.85mL

37.00mL

7.40mL

3.70mL
参考文献

[1]Jochems J, et al. Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailability. Neuropsychopharmacology. 2014 Jan;39(2):389-400.

[2]Regna NL, et al. Specific HDAC6 inhibition by ACY-738 reduces SLE pathogenesis in NZB/W mice. Clin Immunol. 2016 Jan;162:58-73.