MMV390048

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Chemical Structure| 1314883-11-8 同义名 : -
CAS号 : 1314883-11-8
货号 : A210038
分子式 : C18H14F3N3O2S
纯度 : 99%+
分子量 : 393.38
MDL号 : MFCD28502126
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(266.92 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 MMV390048 is an antimalarial compound belonging to the aminopyridine class for treating malaria. It is efficacious against all Plasmodium life cycle stages, apart from late hypnozoites in the liver.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.54mL

0.51mL

0.25mL

12.71mL

2.54mL

1.27mL

25.42mL

5.08mL

2.54mL
参考文献

[1]Sonopo MS, Pillay A, et al. Carbon-14 radiolabeling and tissue distribution evaluation of MMV390048. J Labelled Comp Radiopharm. 2016 Dec;59(14):680-688.

[2]Paquet T, Le Manach C, et al. Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Sci Transl Med. 2017 Apr 26;9(387).