Citarinostat

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Chemical Structure| 1316215-12-9 同义名 : ACY241; HDAC-IN-2
CAS号 : 1316215-12-9
货号 : A207811
分子式 : C24H26ClN5O3
纯度 : 99%+
分子量 : 467.95
MDL号 : MFCD28023593
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(64.11 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • HDAC8

    HDAC8, IC50:137 nM

  • HDAC3

    HDAC3, IC50:46 nM

  • HDAC6

    HDAC6, IC50:2.6 nM

  • HDAC2

    HDAC2, IC50:45 nM

  • HDAC1

    HDAC1, IC50:35 nM
描述 Citarinostat (ACY241) is an orally available, and highly selective inhibitor of HDAC6, showing an IC50 of 2.6 nM. Its selectivity extends across other HDAC isoforms as well, with IC50 values of 35 nM, 45 nM, 46 nM, and 137 nM for HDAC1, HDAC2, HDAC3, and HDAC8, respectively, suggesting its potential for anticancer applications[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.14mL

0.43mL

0.21mL

10.68mL

2.14mL

1.07mL

21.37mL

4.27mL

2.14mL
参考文献

[1]Huang P, et al. Selective HDAC inhibition by ACY-241 enhances the activity of NSC 125973 in solid tumor models. Oncotarget. 2017 Jan 10;8(2):2694-2707.