4-Quinolinol

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Chemical Structure| 611-36-9 同义名 : Kynurine; 4-Hydroxyquinoline; 4-Quinolone; NSC 3183
CAS号 : 611-36-9
货号 : A207237
分子式 : C9H7NO
纯度 : 97%
分子量 : 145.16
MDL号 : MFCD00006777
存储条件:

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(723.35 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

生物活性
描述 4-Quinolone (Kynurine) is a derivative of quinoline. The Kynurine pathway, which modulates tryptophan metabolism, plays a role in neuroprotection and influences tumor cell dynamics[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.89mL

1.38mL

0.69mL

34.44mL

6.89mL

3.44mL

68.89mL

13.78mL

6.89mL

参考文献

[1]Pellicciari R, et al. Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase. Adv Exp Med Biol. 2003;527:621-8.

[2]Marija Pinne, et al. Cytochrome P450 Gene Regulation: Reporter Assays to Assess Aryl Hydrocarbon Receptor (HLHE76, AhR) Activation and Antagonism. Cytochrome P450. pp 157-174.

[3]Opitz CA, et al. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature. 2011 Oct 5;478(7368):197-203.