Hycanthone

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Chemical Structure| 3105-97-3 同义名 : -
CAS号 : 3105-97-3
货号 : A204944
分子式 : C20H24N2O2S
纯度 : 95%
分子量 : 356.48
MDL号 : MFCD00083383
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 12 mg/mL(33.66 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Hycanthone is a thioxanthenone derivative that acts as a DNA intercalator, inhibiting both RNA synthesis and DNA topoisomerases I and II. It disrupts nucleic acid biosynthesis and directly binds to apurinic endonuclease-1 (APE1) with a dissociation constant (KD) of 10 nM. Hycanthone is an active metabolite of Lucanthone, functioning as an anti-schistosomal agent[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.81mL

0.56mL

0.28mL

14.03mL

2.81mL

1.40mL

28.05mL

5.61mL

2.81mL
参考文献

[1]Mamta D Naidu, et al. Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding. PLoS One. 2011;6(9):e23679.

[2]Pica Mattoccia L, et al. Effect of hycanthone administered in vivo upon the incorporation of radioactive precursors into macromolecules of Schistosoma mansoni. Mol Biochem Parasitol. 1983 Jun;8(2):99-107.

[3]Hahon N, et al. Action of antischistosomal drugs, hycanthone and its analog 1A-4 N-oxide, on viral interferon induction. J Toxicol Environ Health. 1980 Jul;6(4):705-12.