Sirtinol

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Chemical Structure| 410536-97-9 同义名 : Sir Two Inhibitor Naphthol
CAS号 : 410536-97-9
货号 : A204147
分子式 : C26H22N2O2
纯度 : 98%+
分子量 : 394.47
MDL号 : MFCD00810186
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 9 mg/mL(22.82 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • SIRT1

    SIRT1, IC50:131 μM

  • SIRT2

    SIRT2, IC50:38 μM
描述 Sirtinol is an inhibitor of sirtuin (SIRT), with IC50 values of 48 μM, 57.7 μM, and 131 μM for ySir2, hSIRT2, and hSIRT2, respectively[1][2][3][4].
细胞研究
细胞系 浓度 检测类型 检测时间 活性说明 数据源
human MCF7 cells 30 μM Proliferation assay 24-72 h Antiproliferative activity against human MCF7 cells at 30 uM after 24 to 72 hrs 24340169
human MCF7 cells 50 μM Function assay 24 h Inhibition of SIRT1 in human MCF7 cells assessed as increase in acetylation of p53 at lys 382 at 50 uM after 24 hrs by Western blot analysis 24340169
human U937 cells 50 μM Apoptosis assay 45 h Induction of apoptosis in human U937 cells at 50 uM after 45 hrs by flow cytometry 23189967
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.54mL

0.51mL

0.25mL

12.68mL

2.54mL

1.27mL

25.35mL

5.07mL

2.54mL
参考文献

[1]Wang J, et al. Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells. Int J Oncol. 2012 Sep;41(3):1101-1109.

[2]Fong Y, et al. The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/β-catenin-Foxo3a axis. ScientificWorldJournal. 2014;2014:937051.

[3]Mai A, et al. Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J Med Chem. 2005 Dec 1;48(24):7789-95.

[4]Tsai YF, et al. Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in mice. Sci Rep. 2015 Feb 10;5:8347.